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Pancreatic Enzymes Improve Digestion to Reduce Malabsorption Pan 5 Xtra Capsules Digest 70-85 Times Their Weight in Dietary Fats, Starches and Proteins Pancreatic enzymes are important in hydrolysis of proteins, carbohydrates and fats into metabolically useful elements — amino acids, sugars, fatty acids and glycerol. Pan 5 Xtra is so abundant in pancreatic enzymes that one capsule will digest: Pan 10 Xtra is twice that strength. Enteric coated pancreatin tablets were used as digestive aids for a number years before clinical trials showed the tablets to be more effective when the enteric coating was removed and the tablets crushed and administered in capsule form.(1) Pan 5 Xtra and Pan 10 Xtra are supplied as powdered supplements in capsule form. It is important to note that the functionality of pancreatic enzymes is enhanced by other enzyme systems including salivary amylase, gastric pepsin and intestinal saccharides. Oral Supplements Increase Enzyme Activity to Nearly Normal in Cases of Pancreatic Insufficiency In a study on the therapeutic response to oral enzymes in severe pancreatic insufficiency, researchers concluded that "...the administration of these high potency digestive aids, along with meals, does have a very positive clinical influence on reducing malabsorption through improved digestion — when comparing a healthy pancreatic sufficient individual to one with pancreatic insufficiency, the use of pancreatin with meals greatly increases the fat-splitting enzyme activity in the duodenum to nearly normal levels."(3) Without sufficient pancreatic enzymes, digestion will be incomplete, resulting in malabsorption, multiple nutritional deficiencies and a host of related symptoms. Oral enzyme supplements have been effectively used therapeutically in cases of: Of the myriad of approximately 30 identified pancreatic enzymes present in Pan 5 Xtra and Pan 10 Xtra, amylase, lipase and protease are considered to be of greatest physiological importance. Pan 5 Xtra and Pan 10 Xtra were designed primarily as digestive aids. The combination of enzymes in the Inflamase formula are more effective as an anti-inflammatory. Effective Therapeutic Use of Enzyme Supplements Effective enzyme therapy requires the administration of sufficient quantities of replacement enzymes. The in vitro activity can be related directly to in vivo potency.(1) Pan 5 Xtra is a potent and effective digestive aid. Our most potent supplement, Pan 10 Xtra may be used for inflammation and digestive support in acute or severe cases of pancreatic insufficiency, but should not be used for prolonged periods by persons with a healthy, normally functioning pancreas. Gastric acidity and possibly low duodenal pH may interfere with effective enzyme replacement in some patients. For these patients, the addition of an antacid may be indicated. The pH barrier is usually not a grave problem because hyperacidity is rare in patients with exocrine pancreatic insufficiency; whereas, hypochlorhydria and achlorhydria are common findings.(1) High fat diets inhibit pancreatic enzyme utilization, which is one of the main causes of protein malabsorption;(2) therefore, supplements will be more effective if a low fat diet is followed. Used as a digestive aid, pancreatic enzyme supplements should be taken with meals or at the end of a meal. Proteolytic enzymes used for inflammation or to reduce swelling and speed healing in soft tissue injuries should be taken between meals, on an empty stomach, for maximum effectiveness. WARNING: This publication and the products contained herein have not been approved or evaluated by the Food and Drug Administration. This publication, and the products contained herein are not intended to diagnose, treat, cure or prevent any disease. The product relates to nutritional support only. REFERENCES 1. Graham, David Y., M.D., "Enzyme Replacement Therapy of Exocrine Pancreatic Insufficiency in Man", New England Journal of Medicine, 296:1314-1317 , June 9, 1977. 2. Bland, Jeffrey, Ph.D., "Glandular Based Food Supplements: Helping to Separate Fact from Fiction", University of Puget Sound, 1980. 3. DiMagno, E.P., "Comparative Effects of Antacids, Cimetidine and Enteric Coating on the Therapeutic Response to Oral Enzymes in Severe Pancreatic Insufficiency", New England Journal of Medicine, 297:854-858, October 20, 1977. 4. Gyr, K., Felsenfeld, O. and Zimmerli-Ning, M., "The Effect of Oral Pancreatic Enzymes on the Intestinal Flora of Protein Deficient Vervet Monkeys challenged with Vibrio Cholerae," American Journal of Clinical Nutrition, 32:1952, 1979. 5. Cichoke, Anthony J, D.C., "The use of Proteolytic Enzymes with Soft Tissue Athletic Injuries", The American Chiropractor, page 32, September/October, 1981. 6. Murray, M., Pizzorno, J., Encyclopedia of Natural Medicine, Prima Publishing, Rocklin, CA, 1991. 7. Barba A., et al, "Pancreatic exocrine function in rosacea", Dermatologica, 164:601-6, 1982. PAN 5 Xtra 5X USP Raw Pancreas Enzyme Concentrate Each capsule supplies the following minimum pancreatic enzyme activity: Amylase 40.000 U.S.P. Units Protease 40,000 U.S.P. Units Lipase 7,500 U.S.P. Units Ingredients: raw porcine pancreas concentrate, rice flour, vegetable stearine, gelatin, magnesium stearate. Suggested Use: One to four capsules at the end of each meal as a digestive aid. Product No. 964 Fill Size: 90 capsules Price: $23.00 Product No. 9642 Fill Size: 250 capsules Price: $57.00 PAN 10 Xtra 10X USP Raw Pancreas Enzyme Concentrate Each capsule supplies the following minimum pancreatic enzyme activity: Amylase 80,000 U.S.P. Units Protease 80,000 U.S.P. Units Lipase 15,000 U.S.P. Units Ingredients: raw porcine pancreas concentrate, rice flour, vegetable stearine, gelatin, magnesium stearate. Suggested Use: One to six capsules daily with meals for severe pancreatic insufficiency. Take between meals for parasites or inflammatory conditions. The raw pancreas enzyme concentrate in these products is prepared by a special process which does not exceed physiological temperature (37° C). Guaranteed to be free of chemical pesticides and synthetic hormones. Product No. 428 Fill Size: 90 capsules Price: $29.00 Product No. 4282 Fill Size: 250 capsules Price: $79.00 Copyright 2004 Alternative Medicine Shop, LLC. |
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